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Case Reports in Hematology
Volume 2013, Article ID 513049, 3 pages
http://dx.doi.org/10.1155/2013/513049
Case Report

BRAF V600E-Negative Hairy Cell Leukaemia

1Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James’s Hospital, Dublin 8, Ireland
2Department of Haematology, St. James’s Hospital, Dublin, Ireland
3Department of Haematology, Trinity College Dublin, Dublin, Ireland

Received 8 February 2013; Accepted 25 March 2013

Academic Editors: E. Arellano-Rodrigo, G. Pihan, D. Rund, and S. D. Wagner

Copyright © 2013 Stephen E. Langabeer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed.