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Case Reports in Hematology
Volume 2013, Article ID 541783, 6 pages
Case Report

Cutaneous Plasmablastic Lymphoma in an Immunocompetent Patient with Long-Term Pyrimethamine Use for Essential Thrombocythemia: A Case Report and Literature Review

1Southern Blood and Cancer Service, Dunedin Hospital, Private Bag 1921, Dunedin 9054, New Zealand
2Division of Haematology, Southern Community Laboratories, Dunedin 9016, New Zealand

Received 4 December 2012; Accepted 10 January 2013

Academic Editors: E. Bissé, K. Khair, S. Langabeer, Y. Matsukawa, A. Ohsaka, Y. Shiozawa, and T. Sonoki

Copyright © 2013 Ing Soo Tiong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a case of Epstein-Barr-virus-(EBV-) positive primary cutaneous plasmablastic lymphoma in a human-immunodeficiency-virus-(HIV-) negative, immunocompetent 62-year-old female patient. We postulate that her lymphoma development is due to the longstanding use of pyrimethamine for essential thrombocythemia. This has never been described in the literature.