Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy

Table 1

Laboratory parameters 3 weeks after PEG-Asparginase therapy.

Laboratory parameters	Reference ranges	Patient results
PT/INR	10.1–13.6 seconds/0.9–1.2	18.7/1.7 seconds
aPTT	24–36 seconds	39 seconds
D-Dimer	0–0.5 mg/L	1.67 mg/L
Fibrinogen	1.5–4 g/L	0.6 g/L
Factor VIII activity	0.5–2 IU/mL	>2 IU/mL
Protein C function	0.5–1.24 IU/mL	0.77 IU/mL
Protein S (total/free)	0.52–0.99/0.51–1.18 IU/mL	0.65/0.52 IU/mL
AT-III assay	70%–110%	93%
Anticardiolipin
IgG	<10 GPL/mL	8 GPL/mL
IgA	<7 APL/mL	<2 APL/mL
IgM	<7 MPL/mL	<3 MPL/mL
Homocysteine	5–15 µmol/L	3 µmol/L
Fasting lipid profile
Total cholesterol	0–5 mmol/L	3.9 mmol/L
Triglyceride	0–2.3 mmol/L	1.3 mmol/L
HDL	1–1.5 mmol/L	1.4 mmol/L
LDL	0–2.5 mmol/L	2.2 mmol/L

PT: prothrombin time, aPTT: activated partial thromboplastin time.