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Case Reports in Hematology
Volume 2013 (2013), Article ID 934781, 4 pages
http://dx.doi.org/10.1155/2013/934781
Case Report

Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin

1Department of Hematology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway
2Department of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway
3Institute of Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway
4Department of Nuclear Medicine, Oslo University Hospital, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway
5Section for Cancer Cytogenetics, Institute for Medical Informatics, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway
6Department of Oncology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, Norway
7Department of Pathology, Oslo University Hospital, Radiumhospitalet, P.O. Box 4950, Nydalen, 0424 Oslo, Norway

Received 2 August 2013; Accepted 12 September 2013

Academic Editors: E. Arellano-Rodrigo, N. Hamerschlak, and S. Tauro

Copyright © 2013 Yngvar Fløisand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia. These rare malignancies have been shown to share a common clonal origin, often deduced from the finding of isochromosome 12p, i(12p), in cells from both the solid tumor and the leukemia, and thus are now known to represent different manifestations of the same clonal process. We treated a young female patient with a malignant phyllodes tumor followed by an acute megakaryoblastic leukemia and found several of the same marker chromosomes by karyotype analysis of cells from both the tumor and the leukemia implying a common clonal origin of the two. To the best of our knowledge, this has not been demonstrated in phyllodes tumors before, but indicates that the same type of leukemization may occur of this tumor as has been described in mediastinal GCT.