A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature

Figure 1

H & E and immunohistochemical staining of follicular components. Hematoxylin and eosin stained sections showed numerous neoplastic follicles occupying almost the entire lymph node, effacing the normal nodal architecture extending from the cortex to the hilum, and invading beyond the capsule ((a) 4x). The neoplastic follicles consist of small centrocytes with ovoid shape, small angulated nuclei, clumped chromatin, and inconspicuous or absent nucleoli. Rare intermixed centroblasts are seen ((b) 20x and (c) 40 xs). Immunohistochemical staining revealed the germinal center cells expressing the pan B-cell marker CD20 ((d) 10x) in addition to germinal center-associated markers CD10 ((e) 10x), BCL-6 ((f) 10x), and BCL-2 ((g) 10x). The collective histologic and immunophenotype findings indicated a follicular lymphoma, grade 1 of 3.

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