A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature

Table 2

MCL in situ with FL.

Case number	Histology	Immunohistochemistry; flow cytometry	FISH/southern blot/PCR	Tissue microdissection	Molecular technique to determine clonal relationships	Results interpretation	Ref
1	MCL: In situ; FL: LG/G1	In situ MCL: CD5−; cyclin D1+; CD23−; FL: CD10+; BCL2+	NA	Not done	Not done	Not known	[5]
2	MCL: In situ; FL: LG/G1	In situ MCL: CD5+; cyclin D1+; CD23−; FL: CD10+; BCL2+	t +; t(14; 18) +	Performed	IgH PCR FR1 FR3 JH	Clonally related	[6]
3	MCL: In situ; FL: LG/G1-2, in situ	In situ MCL: CD5−; cyclin D1+; CD23−; FL: CD10+; BCL2−; In situ FL: CD10+; BCL2+	t +; t+	Performed	IgH PCR FR2 D1–6 IgL PCR Vk/Kde	Clonally related	[7]
4	MCL: In situ; FL: Stage 4B	In situ MCL: CD5−; cyclin D1+; CD23−; FL: CD10+; BCL2+	NA	Not done	Not Done	Not known	[8]
5	MCL: In situ; FL: NA	In situ MCL: CD5+; cyclin D1−; CD23−; FL: CD10+; BCL2+	t +; t +	Performed	PCR for IgH	Clonally related	[9]
6	MCL: In situ; FL: NA	In situ MCL: CD5+; cyclin D1+; CD23 NA; FL: CD10+; BCL2+	t +; t +	Performed	PCR for IgH	Clonally related	[9]