Table 2: MCL in situ with FL.

Case numberHistologyImmunohistochemistry
flow cytometry
FISH/southern blot/PCRTissue microdissectionMolecular technique to determine clonal relationshipsResults interpretationRef

1MCL: In situ
FL: LG/G1
In situ MCL: CD5−; cyclin D1+; CD23−
FL: CD10+; BCL2+
NANot doneNot doneNot known[5]

2MCL: In situ
FL: LG/G1
In situ MCL: CD5+; cyclin D1+; CD23−
FL: CD10+; BCL2+
t +
t(14; 18) +
PerformedIgH PCR FR1 FR3 JHClonally related[6]

3MCL: In situ
FL: LG/G1-2, in situ
In situ MCL: CD5−; cyclin D1+; CD23−
FL: CD10+; BCL2−
In situ FL: CD10+; BCL2+
t +
t+
PerformedIgH PCR FR2 D1–6 IgL PCR Vk/KdeClonally related[7]

4MCL: In situ
FL: Stage 4B
In situ MCL: CD5−; cyclin D1+; CD23−
FL: CD10+; BCL2+
NANot doneNot DoneNot known[8]

5MCL: In situ
FL: NA
In situ MCL: CD5+; cyclin D1−; CD23−
FL: CD10+; BCL2+
t +
t +
PerformedPCR for IgHClonally related[9]

6MCL: In situ
FL: NA
In situ MCL: CD5+; cyclin D1+; CD23 NA
FL: CD10+; BCL2+
t +
t +
PerformedPCR for IgHClonally related[9]