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Case Reports in Hematology
Volume 2014 (2014), Article ID 310750, 4 pages
Case Report

Recurrent and Progressive Abdominal Pain and Enteritis in a Japanese Patient with Paroxysmal Nocturnal Hemoglobinuria

1Department of Internal Medicine, Minoh City Hospital, 7-1 Kayano 5-chome, Minoh City, Osaka 562-0014, Japan
2Department of Hematology and Chemotherapy, Osaka Medical Center for Cancer and Cardiovascular Diseases, 8-13F, 1-3-2 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan

Received 14 May 2013; Accepted 24 June 2013; Published 27 January 2014

Academic Editors: E. Arellano-Rodrigo, K. Konstantopoulos, and F. Kutlar

Copyright © 2014 Akihisa Hino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This case report describes a young male patient with recurrent abdominal pain persisting for more than 16 months. Clinical investigations showed signs of inflammation and pancytopenia. A diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) was made 9 months after the onset of the abdominal pain, following endoscopic examinations that revealed evidence of a previously unknown hemorrhage. Regular monitoring indicated that the abdominal pain was associated with elevations in lactate dehydrogenase, C-reactive proteins, and D-dimer levels. The patient started treatment with the complement inhibitor eculizumab shortly after it was approved for use in Japanese PNH patients with hemolysis. Resolution of the abdominal pain and normalization of clinical parameters were noted within 3 weeks from treatment initiation.