Aberrant “Barbed-Wire” Nuclear Projections of Neutrophils in Trisomy 18 (Edwards Syndrome)

Table 1

Summary of case information in articles describing aberrant nuclear projections associated with chromosomal trisomies.

Report (year)	Number of cases	Trisomy chromosome	Nuclear projections
			Description	# per cell	Size	% of neutrophils
Huehns et al. (1964) [9]	6	D group	Extremely variable, sessile, pedunculated	1–6	0.25–1.5 µm	ND
Powars et al. (1964) [12]	1	D group	Hook-like	ND	<2.0 µm	63%
Lutzner and Hecht (1966) [10]	11	D group (); C group ()	Varied greatly in size and shape, tags, threads, clubs, drumstick-like	1–10	ND	60–80%
Walzer et al. (1966) [11]	11	D group	Variable, spherical, ovoid or club shaped	1–4	0.5–1.5 µm	15–52%; Ave. = 26%
Dallapiccola et al. (1984) [14]	1	Mosaic 14	Sessile, pedunculated	3–6	0.25–1.5 µm	40%
Salama et al. (2004) [13]	1	13	Thread-like	>2	ND	80%

(Ave.: average; ND: not determined).