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Case Reports in Hematology
Volume 2015, Article ID 201536, 5 pages
http://dx.doi.org/10.1155/2015/201536
Case Report

Pulmonary Langerhans Cell Histiocytosis with Lytic Bone Involvement in an Adult Smoker: Regression following Smoking Cessation

1Division of Haematology and Oncology, McGill University Health Centre (MUHC), Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC, Canada H3G 1A4
2Department of Medicine, Division of Internal, McGill University Health Centre (MUHC), Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC, Canada H3G 1A4
3Department of Medicine, Division of Respirology, McGill University Health Centre (MUHC), Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC, Canada H3G 1A4

Received 1 December 2014; Revised 22 January 2015; Accepted 25 January 2015

Academic Editor: Simon D. Wagner

Copyright © 2015 B. Routy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Grana, “Langerhans cell histocytosis,” Cancer Control, vol. 21, no. 4, pp. 328–343, 2014. View at Google Scholar
  2. H. Carstensen and K. Ornvold, “The epidemiology of LCH in children in Denmark, 1975–89,” Medical and Pediatric Oncology, vol. 21, p. 387, 1993. View at Google Scholar
  3. G. Badalian-Very, J.-A. Vergilio, B. A. Degar et al., “Recurrent BRAF mutations in Langerhans cell histiocytosis,” Blood, vol. 116, no. 11, pp. 1919–1923, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M.-C. Aubry, J. L. Wright, and J. L. Myers, “The pathology of smoking-related lung diseases,” Clinics in Chest Medicine, vol. 21, no. 1, pp. 11–35, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Vassallo, J. H. Ryu, T. V. Colby, T. Hartman, and A. H. Limper, “Pulmonary Langerhans-cell histiocytosis,” The New England Journal of Medicine, vol. 342, no. 26, pp. 1969–1978, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Bernstrand, K. Cederlund, B. Sandstedt et al., “Pulmonary abnormalities at long-term follow-up of patients with langerhans cell histiocytosis,” Medical and Pediatric Oncology, vol. 36, no. 4, pp. 459–468, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Tazi, “Adult pulmonary Langerhans' cell histiocytosis,” European Respiratory Journal, vol. 27, no. 6, pp. 1272–1285, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. W. D. Travis, Z. Borok, J. H. Roum et al., “Pulmonary Langerhans cell granulomatosis (histiocytosis X): a clinicopathologic study of 48 cases,” The American Journal of Surgical Pathology, vol. 17, no. 10, pp. 971–986, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. S. A. Yousem, S. Dacic, Y. E. Nikiforov, and M. Nikiforova, “Pulmonary langerhans cell histiocytosis,” Chest, vol. 143, no. 6, pp. 1679–1684, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. A. C. Roden, X. Hu, S. Kip et al., “BRAF V600E expression in Langerhans cell histiocytosis,” The American Journal of Surgical Pathology, vol. 38, no. 4, pp. 548–551, 2014. View at Google Scholar
  11. R. Vassallo, J. H. Ryu, D. R. Schroeder, P. A. Decker, and A. H. Limper, “Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults,” The New England Journal of Medicine, vol. 346, no. 7, pp. 484–490, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Karpathiou, A. Koutsopoulos, and M. E. Froudarakis, “A rare case of ‘switch on and off’ multi-system Langerhans cell histiocytosis in an adult patient,” Journal of Medical Case Reports, vol. 5, no. 1, article 302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. W. J. Shih, G. L. Shih, and P. Milan, “Langerhans cell histiocytosis of the lung with probably skeletal involvement,” Hellenic Journal of Nuclear Medicine, vol. 14, no. 1, pp. 65–67, 2011. View at Google Scholar · View at Scopus
  14. M. Nakamura, M. Okamoto, S. Momosaki et al., “A case of pulmonary Langerhans cell histiocytosis with panhypopituitarism,” Nihon Kokyūki Gakkai Zasshi, vol. 49, no. 2, pp. 116–121, 2011. View at Google Scholar · View at Scopus
  15. B. D. Medoff, G. F. Abbott, and A. Louissaint Jr., “Case 16-2010: a 48-year-old man with a cough and pain in the left shoulder,” The New England Journal of Medicine, vol. 362, no. 21, pp. 1958–2022, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. S. A. Yousem, S. Dacic, Y. E. Nikiforov, and M. Nikiforova, “Pulmonary langerhans cell histiocytosis: profiling of multifocal tumors using next-generation sequencing identifies concordant occurrence of BRAF V600E mutations,” Chest, vol. 143, no. 6, pp. 1679–1684, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Mogulkoc, A. Veral, P. W. Bishop, Ü. Bayindir, C. A. C. Pickering, and J. J. Egan, “Pulmonary Langerhans' cell histiocytosis: radiologic resolution following smoking cessation,” Chest, vol. 115, no. 5, pp. 1452–1455, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Ladisch and H. Gadner, “Treatment of Langerhans cell histiocytosis—evolution and current approaches,” The British Journal of Cancer. Supplement, vol. 23, pp. S41–S46, 1994. View at Google Scholar · View at Scopus
  19. N. A. Zeid and H. K. Muller, “Tobacco smoke induced lung granulomas and tumors: association with pulmonary Langerhans cells,” Pathology, vol. 27, no. 3, pp. 247–254, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Aicher, C. Heeschen, M. Mohaupt, J. P. Cooke, A. M. Zeiher, and S. Dimmeler, “Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions,” Circulation, vol. 107, no. 4, pp. 604–611, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Haroche, F. Cohen-Aubart, J. T. Emile et al., “Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation,” Blood, vol. 121, no. 9, pp. 149–500, 2013. View at Publisher · View at Google Scholar