Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma

Figure 3

(a, b, c) Flow cytometric analysis of the bone marrow, following induction I chemotherapy. The dominant cell population, 56% of nonerythroid cells (green), was consistent with abnormal hypogranular promyelocytes that expressed neither CD11b nor HLA-DR but were highly autofluorescent. (d, e, f) Similar analysis of bone marrow, following induction II, demonstrated the appropriate right angle light scatter for promyelocytes (vertical red line) with the majority of maturing myeloid cells now expressing CD11b, that is, myelocytes-segmented neutrophils.