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Case Reports in Hematology
Volume 2015 (2015), Article ID 876752, 4 pages
http://dx.doi.org/10.1155/2015/876752
Case Report

Rare Form of Erdheim-Chester Disease Presenting with Isolated Central Skeletal Lesions Treated with a Combination of Alfa-Interferon and Zoledronic Acid

1First Pavlov State Medical University of St. Petersburg, L’va Tolstogo Street, No. 6/8, Saint Petersburg 197022, Russia
2University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany

Received 19 December 2014; Revised 18 March 2015; Accepted 19 March 2015

Academic Editor: Ramon Tiu

Copyright © 2015 E. N. Bulycheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Erdheim-Chester disease (ECD) represents a clonal non-Langerhans histiocytosis, which manifests under an extensive variety of clinical symptoms. This creates a challenge for the physician, who is required to recognize and diagnose the disease in the early stages. Despite this considerable challenge, in the last decade there has been a dramatic increase in ECD diagnoses, in most part due to an increasing awareness of this rare disorder. Involvement of the axial skeleton is exclusively uncommon with no official recommendations for the treatment of the bone lesions. Here, we present a case report of a young male patient with isolated lesions of the spine, ribs, and pelvis, who was successfully treated with a combination therapy of alfa-interferon and zoledronic acid.