Rare Form of Erdheim-Chester Disease Presenting with Isolated Central Skeletal Lesions Treated with a Combination of Alfa-Interferon and Zoledronic Acid

Figure 3

Immunohistochemistry. (a) Staining for CD68, 200. Prominent expression of CD68 in xanthoma and giant multinuclear cells. (b) Staining for S-100, 400. Less than 5% of the xanthoma cells express S-100. (c) Staining for FXIIIa, 400. 10–15% xanthoma cells have nuclear-cytoplasmic expression of FXIIIa.

(a)

(b)

(c)