Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib

Table 1

Summary of cases of Mycobacterium tuberculosis after receipt of ruxolitinib described in the literature.

	Case	Case	Case	Case	Case	Case	Case
Age (y)/sex	78/F	78/F	72/M	68/M	82/M	65/F	62/M
Infection	Disseminated TB	Disseminated TB	Miliary TB	Pulmonary TB	Reactivated pulmonary TB	Extrapulmonary TB	Disseminated TB
Timing of infection after start of ruxolitinib	1.5 years	Unspecified	5 months	4 weeks	2 months	4 months	7 weeks
Treatment of infection	ATT	ATT	ATT	ATT	ATT	ATT	ATT
Resolution of infection after treatment		Yes	No	No	Yes	Yes	Yes
Ruxolitinib therapy after diagnosis of infection	Continued	Discontinued at diagnosis of infection	Discontinued	Discontinued	Discontinued	Discontinued	Discontinued
Reintroduction of ruxolitinib during treatment of infection	Ruxolitinib continued without interruption	No	No	No	No	Restarted after 6 months of ATT	Restarted
Ruxolitinib resumed after completion of infection treatment	Continued without interruption	Unspecified	No	No	Unspecified	Ruxolitinib continued with isoniazid prophylaxis	Continued
Relapse of infection	No	No	N/A	N/A	No	No	No
Outcome	Alive	Alive	Died	Died	Alive	Alive	Alive
Year/reference	2016/[5]	2015/[12]	2015/[10]	2015/[10]	2015/[6]	2015/[11]	2014/[9]