Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2016, Article ID 3947510, 4 pages
Case Report

Lymphoma Heterogeneity: Three Different Histological Pictures and One Unique Clone

1Hematology Department, University Hospital of Salamanca, Salamanca, Spain
2Pathology Department, University Hospital of Salamanca, Salamanca, Spain

Received 29 April 2016; Revised 7 September 2016; Accepted 19 September 2016

Academic Editor: Sotirios G. Papageorgiou

Copyright © 2016 Sara Alonso-Alvarez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a patient who developed up to three different lymphomas with the same clonal IGH rearrangement. She was first diagnosed of splenic zone marginal lymphoma and relapsed for the first time with Hodgkin lymphoma histology and later with diffuse large B-cell lymphoma histology. Subsequent biopsies and analysis of clonally rearranged IGH genes helped to elucidate the clonal relationship between the three histologies and to confirm a common origin from the three tissue histologies. An integrated diagnosis should always be performed in order to achieve the most accurate diagnosis and be able to choose the best therapeutic options for our patients.