Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2016 (2016), Article ID 5403612, 4 pages
http://dx.doi.org/10.1155/2016/5403612
Case Report

Balancing Therapy with Thrombopoietin Receptor Agonists and Splenectomy in Refractory Immune Thrombocytopenic Purpura: A Case of Postsplenectomy Thrombocytosis Requiring Plateletpheresis

Division of Hematology, Johns Hopkins University, Baltimore, MD, USA

Received 12 May 2016; Accepted 7 August 2016

Academic Editor: Salah Aref

Copyright © 2016 Jacquelyn Zimmerman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Wei, X.-B. Ji, Y.-W. Wang et al., “High-dose dexamethasone vs prednisone for treatment of adult immune thrombocytopenia: a prospective multicenter randomized trial,” Blood, vol. 127, no. 3, pp. 296–302, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. D. B. Cines, J. B. Bussel, H. A. Liebman, and E. T. Luning Prak, “The ITP syndrome: pathogenic and clinical diversity,” Blood, vol. 113, no. 26, pp. 6511–6521, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Cheng, R. S. M. Wong, Y. O. Y. Soo et al., “Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone,” The New England Journal of Medicine, vol. 349, no. 9, pp. 831–836, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Neunert, W. Lim, M. Crowther, A. Cohen, L. Solberg Jr., and M. A. Crowther, “The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia,” Blood, vol. 117, no. 16, pp. 4190–4207, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Provan, R. Stasi, A. C. Newland et al., “International consensus report on the investigation and management of primary immune thrombocytopenia,” Blood, vol. 115, no. 2, pp. 168–186, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Weide, S. Feiten, V. Friesenhahn et al., “Outpatient management of patients with immune thrombocytopenia (ITP) by hematologists 1995–2014,” Oncology Research and Treatment, vol. 39, no. 1-2, pp. 41–44, 2016. View at Publisher · View at Google Scholar
  7. W. Ghanima, B. Godeau, D. B. Cines, and J. B. Bussel, “How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment,” Blood, vol. 120, no. 5, pp. 960–969, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Kojouri, S. K. Vesely, D. R. Terrell, and J. N. George, “Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications,” Blood, vol. 104, no. 9, pp. 2623–2634, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Y. Kristinsson, G. Gridley, R. N. Hoover, D. Check, and O. Landgren, “Long-term risks after splenectomy among 8,149 cancer-free American veterans: a cohort study with up to 27 years follow-up,” Haematologica, vol. 99, no. 2, pp. 392–398, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. T. J. González-López, M. T. Alvarez-Román, C. Pascual et al., “Eltrombopag safety and efficacy for primary chronic immune thrombocytopenia in clinical practice,” European Journal of Haematology, vol. 97, no. 3, pp. 297–302, 2016. View at Publisher · View at Google Scholar
  11. P. Mazza, C. Minoia, A. Melpignano et al., “The use of thrombopoietin-receptor agonists (TPO-RAs) in immune thrombocytopenia (ITP): a ‘real life’ retrospective multicenter experience of the Rete Ematologica Pugliese (REP),” Annals of Hematology, vol. 95, no. 2, pp. 239–244, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. M. G. Browning, N. Bullen, T. Nokes, K. Tucker, and M. Coleman, “The evolving indications for splenectomy,” British Journal of Haematology, 2016. View at Publisher · View at Google Scholar
  13. F. Palandri, N. Polverelli, D. Sollazzo et al., “Have splenectomy rate and main outcomes of ITP changed after the introduction of new treatments? A monocentric study in the outpatient setting during 35 years,” American Journal of Hematology, vol. 91, no. 4, pp. E267–E272, 2016. View at Publisher · View at Google Scholar
  14. J. B. Bussel, C. S. Lee, C. Seery et al., “Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration,” Haematologica, vol. 99, no. 7, pp. 1264–1271, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Zaja, W. Barcellini, S. Cantoni et al., “Thrombopoietin receptor agonists for preparing adult patients with immune thrombocytopenia to splenectomy. Results of a retrospective, observational GIMEMA study,” American Journal of Hematology, vol. 91, no. 5, pp. E293–E295, 2016. View at Publisher · View at Google Scholar
  16. T. Uwagawa, T. Misawa, K. Furukawa et al., “Usage of eltrombopag for chronic immune thrombocytopenia as a pretreatment for splenectomy,” Acta Haematologica, vol. 129, no. 1, pp. 45–47, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. M. J. Choe and C. D. Packer, “Severe romiplostim-induced rebound thrombocytopenia after splenectomy for refractory ITP,” Annals of Pharmacotherapy, vol. 49, no. 1, pp. 140–144, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Rodeghiero and M. Ruggeri, “Treatment of immune thrombocytopenia in adults: the role of thrombopoietin-receptor agonists,” Seminars in Hematology, vol. 52, no. 1, pp. 16–24, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. P. N. Khan, R. J. Nair, J. Olivares, L. E. Tingle, and Z. Li, “Postsplenectomy reactive thrombocytosis,” Baylor University Medical Center Proceedings, vol. 22, no. 1, pp. 9–12, 2009. View at Google Scholar
  20. D. H. Buss, A. W. Cashell, M. L. O'Connor, F. Richards II, and L. Douglas Case, “Occurrence, etiology, and clinical significance of extreme thrombocytosis: a study of 280 cases,” The American Journal of Medicine, vol. 96, no. 3, pp. 247–253, 1994. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Baldini, V. Carrai, B. Puccini, L. Rigacci, R. Alterini, and A. Bosi, “Romiplostim before splenectomy in a patient with aggressive non-Hodgkin lymphoma and poor response to platelet transfusions,” Transfusion Medicine, vol. 24, no. 2, pp. 125–126, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Sivera, M. Ruella, A. Gueli, H. Hu, M. Wade, and C. Tarella, “Use of the novel thrombopoietin receptor-agonist romiplostim, in combination with steroids and immunoglobulins for the increase of platelets prior to splenectomy, in refractory immune thrombocytopenia: a case report,” Blood Coagulation & Fibrinolysis, vol. 23, no. 4, pp. 331–334, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. J. S. Raval, R. L. Redner, and J. E. Kiss, “Plateletpheresis for postsplenectomy rebound thrombocytosis in a patient with chronic immune thrombocytopenic purpura on romiplostim,” Journal of Clinical Apheresis, vol. 28, no. 4, pp. 321–324, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. B. B. Yang, S. Doshi, K. Arkam, J. Franklin, and A. T. Chow, “Development of romiplostim for treatment of primary immune thrombocytopenia from a pharmacokinetic and pharmacodynamic perspective,” Clinical Pharmacokinetics, vol. 55, no. 9, pp. 1045–1058, 2016. View at Publisher · View at Google Scholar
  25. Y. Zhang and J. M. Kolesar, “Eltrombopag: an oral thrombopoietin receptor agonist for the treatment of idiopathic thrombocytopenic purpura,” Clinical Therapeutics, vol. 33, no. 11, pp. 1560–1576, 2011. View at Publisher · View at Google Scholar · View at Scopus