Uveitis and Myositis as Immune Complications in Chemorefractory NK/T-Cell Nasal-Type Lymphoma Successfully Treated with Allogeneic Stem-Cell Transplant

Figure 1

(a-b) Nasal lymphoma showing an initial ulcer that perforated into the oral cavity, opening a passage between the oral cavity and the nasal cavity. (c) Cutaneous manifestation of nasal-type extranodal NK/T-cell lymphoma. (d) Skeletal muscle fascicles revealing markedly distorted overall architecture with inflammatory interstitial infiltrate and endo and perimysial expansion. Perivascular lymphocytic inflammatory cluster with no signs of vasculitis. Myopathic changes suggestive of inflammatory myopathy. EBER negative. (e) Flow cytometry analysis of vitreous humor specimen: analysis is performed on cells consistent with leukocytes by FSC versus SSC and CD45. Flow cytometry demonstrates an aberrant NK-cell population (highlighted in red) with the following immunophenotype: CD3s−, CD56 (bright), CD7−, CD45+, HLA-DR−, CD5−, CD8−, and CD4− (see complete immunophenotype in text). Cells highlighted in cyan show a minor population of not aberrant NK cells and cells in red show reactive T cells. (f) MRI of the lower limbs revealing myositis infectious between the extensor digitorum longus and peroneus longus.

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