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Case Reports in Hematology
Volume 2016, Article ID 9495761, 4 pages
http://dx.doi.org/10.1155/2016/9495761
Case Report

Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil

Warwick Hospital, Lakin Road, Warwick, Warwickshire CV34 5BW, UK

Received 13 March 2016; Revised 11 June 2016; Accepted 3 July 2016

Academic Editor: Yoshihiro Matsukawa

Copyright © 2016 Sarah Green et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Valeyre, A. Prasse, H. Nunes, Y. Uzunhan, P.-Y. Brillet, and J. Müller-Quernheim, “Sarcoidosis,” The Lancet, vol. 383, no. 9923, pp. 1155–1167, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. J. J. Swigris, A. L. Olson, T. J. Huie et al., “Sarcoidosis-related mortality in the United States from 1988 to 2007,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 11, pp. 1524–1530, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. G. F. Bass, E. T. Tuscano, and J. M. Tuscano, “Diagnosis and classification of autoimmune hemolytic anemia,” Autoimmunity Reviews, vol. 13, no. 4-5, pp. 560–564, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. A. E. Davis, J. P. Belber, and E. R. Movitt, “The association of hemolytic anemia with sarcoidosis,” Blood, vol. 9, no. 4, pp. 379–383, 1954. View at Google Scholar · View at Scopus
  5. N. Yasuda, M. Kohda, M. Nomura et al., “Sarcoidosis in a patient with autoimmune hemolytic anemia,” Nihon Kyobu Shikkan Gakkai Zasshi, vol. 34, no. 8, pp. 931–936, 1996. View at Google Scholar · View at Scopus
  6. R. K. Ghaddar and T. H. Muzaffar, “Pulmonary sarcoidosis and autoimmune hemolytic anemia: possible common immune pathogenesis,” Archives of Iranian Medicine, vol. 14, no. 2, pp. 146–148, 2011. View at Google Scholar · View at Scopus
  7. K. Chernow, T. Donegan, T. Milman, and D. Henry, “Sarcoidosis, complete heart block, and warm autoimmune hemolytic anemia in a young woman,” The Journal of Community and Supportive Oncology, vol. 13, no. 4, pp. 159–161, 2015. View at Publisher · View at Google Scholar
  8. B. Desablens, A. Pruna, M. F. Gontier, and J. Messerschmitt, “Autoimmune haemolytic anaemia associated with bone marrow sarcoidosis,” Acta Haematologica, vol. 71, no. 3, pp. 204–206, 1984. View at Google Scholar · View at Scopus
  9. S. Wyss and C. Maier, “Hemolytic anemia in sarcoidosis of the spleen,” Acta Haematologica, vol. 37, no. 2, pp. 126–136, 1967. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Meregalli, R. Bosisio, C. L. Delpiano, and M. Spinelli, “Monolateral sarcoidosis of parotid gland associated with hemolytic anemia: description of a case diagnosed by cyto-histology,” Haematologica, vol. 76, no. 4, pp. 321–323, 1991. View at Google Scholar · View at Scopus
  11. U. Thadani, C. P. Aber, and J. J. Taylor, “Massive splenomegaly, pancytopenia and haemolytic anaemia in sarcoidosis,” Acta Haematologica, vol. 53, no. 4, pp. 230–240, 1975. View at Google Scholar · View at Scopus
  12. P. Semple, “Thrombocytopenia, haemolytic anaemia and sarcoidosis,” British Medical Journal, vol. 4, no. 5994, pp. 440–441, 1975. View at Google Scholar · View at Scopus
  13. H. Kondo, S. Sakai, and Y. Sakai, “Autoimmune haemolytic anaemia, Sjogren's syndrome and idiopathic thrombocytopenic purpura in a patient with sarcoidosis,” Acta Haematologica, vol. 89, no. 4, pp. 209–212, 1993. View at Google Scholar · View at Scopus
  14. W. Barcellini, “Current treatment strategies in autoimmune hemolytic disorders,” Expert Review of Hematology, vol. 8, no. 5, pp. 681–691, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. R. P. Baughman, E. E. Lower, and R. M. du Bois, “Sarcoidosis,” The Lancet, vol. 361, no. 9363, pp. 1111–1118, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Facco, A. Cabrelle, A. Teramo et al., “Sarcoidosis is a Th1/Th17 multisystem disorder,” Thorax, vol. 66, no. 2, pp. 144–150, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. K. K. Hoyer, W. F. Kuswanto, E. Gallo, and A. K. Abbas, “Distinct roles of helper T-cell subsets in a systemic autoimmune disease,” Blood, vol. 113, no. 2, pp. 389–395, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. F. L. van de Veerdonk, B. Lauwerys, R. J. Marijnissen et al., “The anti-CD20 antibody rituximab reduces the Th17 cell response,” Arthritis & Rheumatism, vol. 63, no. 6, pp. 1507–1516, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. Reynaud, I. Durieu, M. Dutertre et al., “Efficacy and safety of rituximab in auto-immune hemolytic anemia: a meta-analysis of 21 studies,” Autoimmunity Reviews, vol. 14, no. 4, pp. 304–313, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Hamzeh, A. Voelker, A. Forssén et al., “Efficacy of mycophenolate mofetil in sarcoidosis,” Respiratory Medicine, vol. 108, no. 11, pp. 1663–1669, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. N. O'Connell, M. Goodyer, M. Gleeson et al., “Successful treatment with rituximab and mycophenolate mofetil of refractory autoimmune hemolytic anemia post-hematopoietic stem cell transplant for dyskeratosis congenita due to TINF2 mutation,” Pediatric Transplantation, vol. 18, no. 1, pp. E22–E24, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Abadja, S. Atemkeng, E. Alamartine, F. Berthoux, and C. Mariat, “Impact of mycophenolic acid and tacrolimus on Th17-related immune response,” Transplantation, vol. 92, no. 4, pp. 396–403, 2011. View at Publisher · View at Google Scholar · View at Scopus