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Case Reports in Hematology
Volume 2017 (2017), Article ID 1279525, 6 pages
Case Report

A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax

1Department of Internal Medicine, VieCuri Medical Centre, 5912 BL Venlo, Netherlands
2Department of Pathology, VieCuri Medical Centre, 5912 BL Venlo, Netherlands

Correspondence should be addressed to Mathijs Willemsen

Received 24 January 2017; Accepted 15 March 2017; Published 12 April 2017

Academic Editor: Yusuke Shiozawa

Copyright © 2017 Mathijs Willemsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80–95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor.