A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax

Table 1

Differential diagnostic considerations and results of corresponding diagnostic tests.

Diagnosis	Diagnostic test(s)
Eosinophilic granulomatosis with polyangiitis	No ANCAs and anti-MPO antibodies
Granulomatosis with polyangiitis	No ANCAs and anti-PR3 antibodies
Systemic lupus erythematosus	No ANAs and ENAs; Normal complement C3 (1.4 g/L) and C4 (0.29 g/L)
Antiphospholipid syndrome	Normal IgM and IgG beta-2 glycoprotein (ratio 0.08 and 0.17) and IgM and IgG cardiolipin antibodies (ratios 0.11 and 0.35)
Autoimmune hemolytic anemia	Direct Coombs test negative
Rheumatoid arthritis	Normal RF (24 UI/mL) and ACPAs (0.0 IU/mL)
Cryoglobulinemia	No cryoglobulins
HIV/AIDS	HIV screening negative
Prostate cancer	Low PSA (0.7 µg/L)
Chronic myeloid leukemia (CML)	No BCR-ABL fusion gene
Non-CML myeloproliferative disorders	No JAK2 V617F, JAK2 exon 12, CALR exon 9 or MPL exon 10 mutation
Chronic eosinophilic leukemia; Hypereosinophilic syndrome	No amplification, deletion or rearrangement of FIP1L1-; CHIC2-PDGFRA (4q12), PDGFRB (5q32-33) or FGFR1; (8p12) genes
Multiple myeloma; Waldenström’s macroglobulinemia	Normal serum plasma electrophoresis (albumin 45 g/L, alpha-1 globulin 1 g/L, alpha-2 globulin 10 g/L, beta globulin 8 g/L, gamma globulin 9 g/L)
Upper gastrointestinal malignancy	No dysplasia on endoscopic biopsies

ANCAs: anti-neutrophil cytoplasmic antibodies, MPO: myeloperoxidase, PR3: proteinase 3, ANAs: antinuclear antibodies, ENAs: extractable nuclear antigens (nRNP/Sm, Sm, SSA60, Ro-52, SSB, Scl-70, CENP-B, Jo-1, PM-scl and ribosomal P protein), RF: rheumatoid factor, ACPAs: antibodies to citrullinated protein antigens, HIV: human immunodeficiency virus, AIDS: acquired immune deficiency syndrome, PSA: prostate-specific antigen.