Case Reports in Hematology / 2017 / Article / Tab 1

Case Report

A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax

Table 1

Differential diagnostic considerations and results of corresponding diagnostic tests.

DiagnosisDiagnostic test(s)

Eosinophilic granulomatosis with polyangiitisNo ANCAs and anti-MPO antibodies

Granulomatosis with polyangiitisNo ANCAs and anti-PR3 antibodies

Systemic lupus erythematosusNo ANAs and ENAs
Normal complement C3 (1.4 g/L) and C4 (0.29 g/L)

Antiphospholipid syndromeNormal IgM and IgG beta-2 glycoprotein (ratio 0.08 and 0.17) and IgM and IgG cardiolipin antibodies (ratios 0.11 and 0.35)

Autoimmune hemolytic anemiaDirect Coombs test negative

Rheumatoid arthritisNormal RF (24 UI/mL) and ACPAs (0.0 IU/mL)

CryoglobulinemiaNo cryoglobulins

HIV/AIDSHIV screening negative

Prostate cancerLow PSA (0.7 µg/L)

Chronic myeloid leukemia (CML)No BCR-ABL fusion gene

Non-CML myeloproliferative disordersNo JAK2 V617F, JAK2 exon 12, CALR exon 9 or MPL exon 10 mutation

Chronic eosinophilic leukemia
Hypereosinophilic syndrome
No amplification, deletion or rearrangement of FIP1L1-
CHIC2-PDGFRA (4q12), PDGFRB (5q32-33) or FGFR1
(8p12) genes

Multiple myeloma
Waldenström’s macroglobulinemia
Normal serum plasma electrophoresis (albumin 45 g/L, alpha-1 globulin 1 g/L, alpha-2 globulin 10 g/L, beta globulin 8 g/L, gamma globulin 9 g/L)

Upper gastrointestinal malignancyNo dysplasia on endoscopic biopsies

ANCAs: anti-neutrophil cytoplasmic antibodies, MPO: myeloperoxidase, PR3: proteinase 3, ANAs: antinuclear antibodies, ENAs: extractable nuclear antigens (nRNP/Sm, Sm, SSA60, Ro-52, SSB, Scl-70, CENP-B, Jo-1, PM-scl and ribosomal P protein), RF: rheumatoid factor, ACPAs: antibodies to citrullinated protein antigens, HIV: human immunodeficiency virus, AIDS: acquired immune deficiency syndrome, PSA: prostate-specific antigen.