Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2017, Article ID 2413587, 4 pages
https://doi.org/10.1155/2017/2413587
Case Report

An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma

1Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA
2Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA

Correspondence should be addressed to Nitin Jain; gro.nosrednadm@niajn

Received 28 May 2017; Accepted 8 August 2017; Published 18 September 2017

Academic Editor: Kazunori Nakase

Copyright © 2017 Prajwal Boddu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. H. Swerdlow, “Lymphoma classification and the tools of our trade: An introduction to the 2012 USCAP long course,” Modern Pathology, vol. 26, pp. 1–14, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. B. N. Nathwani, L. W. Diamond, C. D. Winberg et al., “Lymphoblastic lymphoma: A clinicopathologic study of 95 patients,” Cancer, vol. 48, no. 11, pp. 2347–2357, 1981. View at Publisher · View at Google Scholar · View at Scopus
  3. R. A. Soslow, R. N. Baergen, and R. A. Warnke, “B-lineage lymphoblastic lymphoma is a clinicopathologic entity distinct from other histologically similar aggressive lymphomas with blastic morphology,” Cancer, vol. 85, no. 12, pp. 2648–2654, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. S. P. Hunger and C. G. Mullighan, “Acute lymphoblastic leukemia in children,” The New England Journal of Medicine, vol. 373, no. 16, pp. 1541–1552, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. C. G. Mullighan, “Genome sequencing of lymphoid malignancies,” Blood, vol. 122, no. 24, pp. 3899–3907, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. D. A. Thomas, S. Faderl, J. Cortes et al., “Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate,” Blood, vol. 103, no. 12, pp. 4396–4407, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Zhu, S. Zhang, L. Zhu et al., “Primary testicular ph-positive B lymphoblastic lymphoma: An unusual presentation and review,” Cancer Biology and Therapy, vol. 16, no. 8, pp. 1122–1127, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. M. B. Møller, F. d'Amore, and B. E. Christensen, “Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis,” European Journal of Cancer, vol. 30, no. 12, pp. 1760–1764, 1994. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Sahni and S. Desai, “Primary testicular precursor B-lymphoblastic lymphoma: A rare entity,” Leukemia and Lymphoma, vol. 48, no. 10, pp. 2060–2062, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. V. Garcia, B. Alobeid, J. M. Traina, S. S. Chen, M. A. Weiner, and W. Middlesworth, “Isolated primary testicular B lymphoblastic lymphoma: An unusual presentation,” Journal of Pediatric Hematology/Oncology, vol. 35, no. 2, pp. e88–e90, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. A. L. Nashed, K. W. Rao, and M. L. Gulley, “Clinical applications of BCR-ABL molecular testing in acute leukemia,” Journal of Molecular Diagnostics, vol. 5, no. 2, pp. 63–72, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Paietta, J. Racevskis, D. Neuberg, J. M. Rowe, A. H. Goldstone, and P. H. Wiernik, “Expression of CD25 (interleukin-2 receptor α chain) in adult acute lymphoblastic leukemia predicts for the presence of BCR/ABL fusion transcripts: Results of a preliminary laboratory analysis of ECOG/MRC Intergroup Study E2993,” Leukemia, vol. 11, no. 11, pp. 1887–1890, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Jaso, D. A. Thomas, K. Cunningham et al., “Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors,” Cancer, vol. 117, no. 17, pp. 4009–4017, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Ravandi, S. M. O'Brien, J. E. Cortes et al., “Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia,” Cancer, vol. 121, no. 23, pp. 4158–4164, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Daver, D. Thomas, F. Ravandi et al., “Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic Leukemia,” Haematologica, vol. 100, no. 5, pp. 653–661, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. O. B. Eden, A. Rankin, and H. E. M. Kay, “Isolated testicular relapse in acute lymphoblastic leukaemia of childhood. Report on behalf of the Medical Research Council's working party on leukaemia in childhood,” Archives of Disease in Childhood, vol. 58, no. 2, pp. 128–132, 1983. View at Publisher · View at Google Scholar · View at Scopus
  17. D. S. Dave, J. T. Leppert, and J. Rajfer, “Is the testis a chemo-privileged site? Is there a blood-testis barrier?” Reviews in Urology, vol. 9, no. 1, pp. 28–32, 2007. View at Google Scholar