High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a MYC-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification

Figure 4

Immunohistochemistry performed on bone marrow biopsy (first relapse). The abnormal lymphoid cells are positive for PAX-5, BCL-2, cMYC, and TDT (a–d). KI-67 shows high proliferative index (e). The neoplastic cells are negative for CD20 (f). PAX-5 50x (g), cMYC 40x, and Tdt 40x (i).

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