Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2017 (2017), Article ID 6891957, 9 pages
https://doi.org/10.1155/2017/6891957
Case Report

High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a MYC-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification

1Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar
2Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt
3Department of Hematology and Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar

Correspondence should be addressed to Dina Sameh Soliman; aq.damah@namiloSD

Received 13 January 2017; Revised 21 May 2017; Accepted 2 July 2017; Published 13 August 2017

Academic Editor: Tatsuharu Ohno

Copyright © 2017 Dina Sameh Soliman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. D. Jennings and K. A. Foon, “Recent advances in flow cytometry: application to the diagnosis of hematologic malignancy,” Blood, vol. 90, no. 8, pp. 2863–2892, 1997. View at Google Scholar · View at Scopus
  2. Anon, “A clinical evaluation of the International Lymphoma Study Group clas- sification of non-Hodgkins lymphoma. The Non-Hodgkins Lymphoma Classification Project,” Blood, vol. 89, pp. 3909–3918, 1997. View at Google Scholar
  3. M. Hummel, S. Bentink, H. Berger et al., “A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling,” The New England Journal of Medicine, vol. 354, no. 23, pp. 2419–2430, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. V. Moorman, L. Chilton, J. Wilkinson, H. M. Ensor, N. Bown, and S. J. Proctor, “A population-based cytogenetic study of adults with acute lymphoblastic leukemia,” Blood, vol. 115, pp. 206–214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Kansal, G. Deeb, M. Barcos et al., “Precursor B lymphoblastic leukemia with surface light chain immunoglobulin restriction: a report of 15 patients,” American Journal of Clinical Pathology, vol. 121, no. 4, pp. 512–525, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. S. H. Swerdlow, E. Campo, N. L. Harris et al., WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4 edition, 2008.
  7. S. H. Swerdlow, E. Campo, S. A. Pileri et al., “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia,” Blood, vol. 127, no. 20, pp. 2375–2390, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. S. H. Swerdlow, “Diagnosis of 'double hit' diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: When and how, FISH versus IHC,” Hematology, vol. 2014, no. 1, pp. 90–99, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Karube and E. Campo, “MYC Alterations in Diffuse Large B-Cell Lymphomas,” Seminars in Hematology, vol. 52, no. 2, pp. 97–106, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. Johnson N. A., Slack G. W., Savage K. J. et al., “Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone,” Journal of Clinical Oncology, vol. 30, no. 28, pp. 3452–3459, 2012. View at Google Scholar
  11. T. J. Molina, D. Canioni, C. Copie-Bergman et al., “Young patients with non–germinal center B-cell–like diffuse large B-cell lymphoma benefit from intensified chemotherapy with ACVBP plus rituximab compared with CHOP plus rituximab: analysis of data from the Groupe d'Etudes des Lymphomes de l'Adulte/Lymphoma Study Association phase III trial LNH 03-2B,” Journal of Clinical Oncology, vol. 32, no. 35, pp. 3996–4003, 2014. View at Publisher · View at Google Scholar
  12. A. V. Moorman, L. Chilton, J. Wilkinson, H. M. Ensor, N. Bown, and S. J. Proctor, “A population-based cytogenetic study of adults with acute lymphoblastic leukemia,” Blood, vol. 115, pp. 206–214, 2010. View at Google Scholar · View at Scopus
  13. S. Li, P. Lin, L. E. Fayad et al., “B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18) (q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome,” Modern Pathology, vol. 25, no. 1, pp. 145–156, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Snuderl, O. K. Kolman, Y.-B. Chen et al., “B-cell lymphomas with concurrent IGH-BCL2 and MYC Rearrangements are aggressive neoplasms with clinical and pathologic features distinct from burkitt lymphoma and diffuse Large B-cell lymphoma,” American Journal of Surgical Pathology, vol. 34, no. 3, pp. 327–340, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. K. J. Savage, G. W. Slack, A. Mottok et al., “Impact of dual expression of MYC and BCL2 by immunohistochemistry on the risk of CNS relapse in DLBCL,” Blood, vol. 127, no. 18, pp. 2182–2188, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Horn, A. M. Staiger, M. Vöhringer et al., “Diffuse Large B-cell Lymphomas of Immunoblastic Type Are a Major Reservoir for MYC-IGH Translocations,” The American Journal of Surgical Pathology, vol. 39, no. 1, pp. 61–66, 2015. View at Publisher · View at Google Scholar
  17. M. Kimura, M. Yamaguchi, S. Nakamura et al., “Clinicopathologic significance of loss of CD19 expression in diffuse large B-cell lymphoma,” International Journal of Hematology, vol. 85, no. 1, pp. 41–48, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. P. G. Chu, S. Loera, Q. Huang, and L. M. Weiss, “Lineage Determination of CD20- B-Cell Neoplasms: an Immunohistochemical Study,” American Journal of Clinical Pathology, vol. 126, no. 4, pp. 534–544, 2006. View at Publisher · View at Google Scholar
  19. J. Hiraga, A. Tomita, T. Sugimoto et al., “Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: Its prevalence and clinical significance,” Blood, vol. 113, no. 20, pp. 4885–4893, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Cobaleda, W. Jochum, and M. Busslinger, “Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors,” Nature, vol. 449, no. 7161, pp. 473–477, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Moench, Z. Sachs, G. Aasen, M. Dolan, V. Dayton, and E. L. Courville, “Double- and triple-hit lymphomas can present with features suggestive of immaturity, including TdT expression, and create diagnostic challenges,” Leukemia and Lymphoma, vol. 57, no. 11, pp. 2626–2635, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. D. De Jong, B. M. H. Voetdijk, G. C. Beverstock, G. J. B. Van Ommen, R. Willemze, and P. M. Kluin, “Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma,” New England Journal of Medicine, vol. 318, no. 21, pp. 1373–1378, 1988. View at Publisher · View at Google Scholar · View at Scopus
  23. A. M. Harrington, H. Olteanu, S. H. Kroft, and C. Eshoa, “The unique immunophenotype of double-hit lymphomas,” American Journal of Clinical Pathology, vol. 135, no. 4, pp. 649-650, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Loghavi, J. L. Kutok, and J. L. Jorgensen, “B-acute lymphoblastic leukemia/lymphoblastic lymphoma,” American Journal of Clinical Pathology, vol. 144, no. 3, pp. 393–410, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Li, V. L. Weiss, X. J. Wang et al., “High-grade B-cell lymphoma with MYC rearrangement and without BCL2 and BCL6 rearrangements is associated with high P53 expression and a poor prognosis,” American Journal of Surgical Pathology, vol. 40, no. 2, pp. 253–261, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. K. H. Young, Q. Xie, G. Zhou et al., “Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event,” American Journal of Clinical Pathology, vol. 129, no. 1, pp. 157–166, 2008. View at Publisher · View at Google Scholar · View at Scopus