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Case Reports in Hematology
Volume 2017, Article ID 7247438, 3 pages
https://doi.org/10.1155/2017/7247438
Case Report

Posttransplant Lymphoproliferative Disorder in a Patient with Worsening Ascites after Liver Transplantation

1McGovern Medical School, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin St., Suite MSB 1.134, Houston, TX 77030, USA
2McGovern Medical School, Department of Gastroenterology, Transplant and Advanced Hepatology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Suite MSB 1.134, Houston, TX 77030, USA

Correspondence should be addressed to Harsh D. Patel; moc.oohay@18kirah

Received 29 May 2017; Revised 28 July 2017; Accepted 10 August 2017; Published 11 September 2017

Academic Editor: Marie-Christine Kyrtsonis

Copyright © 2017 Harsh D. Patel and Moises I. Nevah Rubin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a spectrum of diseases that involves abnormal lymphoid and/or plasmacytic proliferation in patients with solid organ or hematopoietic cell transplantation. It is a condition with a low incidence of 3.5–4.3% in liver transplant (LT) recipients. This case involves a 63-year-old male with history of LT for chronic HCV induced cirrhosis who presented with abdominal distension related to worsening ascites. Cytological ascitic fluid analysis revealed EBV (+) malignant cells without a malignant focal point on imaging. Diagnosis of monomorphic PTLD with primary effusion lymphoma-like morphology and immunophenotype was established. This case highlights the complexity in diagnosis, different diagnostic modalities, and rare clinical presentations of PTLD.