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Case Reports in Hematology
Volume 2017, Article ID 7657393, 4 pages
https://doi.org/10.1155/2017/7657393
Case Report

Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia

1Cancer Molecular Diagnostics, St. James’s Hospital, Dublin 8, Ireland
2Department of Clinical Genetics, Our Lady’s Children Hospital, Dublin 12, Ireland
3Department of Haematology, Galway University Hospital, Galway, Ireland

Correspondence should be addressed to Stephen E. Langabeer; ei.semajts@reebagnals

Received 24 February 2017; Accepted 9 April 2017; Published 26 April 2017

Academic Editor: Massimo Gentile

Copyright © 2017 Stephen E. Langabeer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Cicconi and F. Lo-Coco, “Current management of newly diagnosed acute promyelocytic leukemia,” Annals of Oncology, vol. 27, no. 8, pp. 1474–1481, 2016. View at Publisher · View at Google Scholar
  2. J. Adams and M. Nassiri, “Acute promyelocytic leukemia a review and discussion of variant translocations,” Archives of Pathology and Laboratory Medicine, vol. 139, no. 10, pp. 1308–1313, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. W. Yan and G. Zhang, “Molecular characteristics and clinical significance of 12 fusion genes in acute promyelocytic leukemia: a systematic review,” Acta Haematologica, vol. 136, no. 1, pp. 1–15, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. S.-J. Chen, A. Zelent, J.-H. Tong et al., “Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia,” Journal of Clinical Investigation, vol. 91, no. 5, pp. 2260–2267, 1993. View at Publisher · View at Google Scholar · View at Scopus
  5. J. D. Licht, C. Chomienne, A. Goy et al., “Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17),” Blood, vol. 85, no. 4, pp. 1083–1094, 1995. View at Google Scholar
  6. D. Sainty, V. Liso, A. Cantù-Rajnoldi, and et al., “A new morphological classification system for acute promyelocytic leukemia distinguishes cases with underlying PLZF/RARA gene rearrangements,” Blood, vol. 96, no. 4, pp. 1287–1296, 2000. View at Google Scholar
  7. F. Guidez, W. Huang, J. H. Tong et al., “Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient,” Leukemia, vol. 8, no. 2, pp. 312–317, 1994. View at Google Scholar
  8. M. A. Sanz, D. Grimwade, M. S. Tallman et al., “Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet,” Blood, vol. 113, no. 9, pp. 1875–1891, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. L. M. Kelly, J. L. Kutok, I. R. Williams et al., “PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 12, pp. 8283–8288, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. L. D. Wartman, D. E. Larson, Z. Xiang et al., “Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression,” Journal of Clinical Investigation, vol. 121, no. 4, pp. 1445–1455, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. S. Welch, T. J. Ley, D. C. Link et al., “The origin and evolution of mutations in acute myeloid leukemia,” Cell, vol. 150, no. 2, pp. 264–278, 2012. View at Publisher · View at Google Scholar
  12. V. Madan, P. Shyamsunder, and L. Han, “Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia,” Leukemia, vol. 30, no. 8, pp. 1672–1681, 2016. View at Google Scholar
  13. L. Riva, C. Ronchini, M. Bodini et al., “Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups,” Blood Cancer Journal, vol. 3, no. 9, p. e147, 2013. View at Publisher · View at Google Scholar
  14. R. Dillon and D. Grimwade, “Prognostic significance of additional cytogenetic abnormalities and FLT3 mutations in acute promyelocytic leukemia,” Leukemia & Lymphoma, vol. 55, no. 7, pp. 1444–1446, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Lai, J. E. Karp, and C. S. Hourigan, “Precision medicine for acute myeloid leukemia,” Expert Review of Hematology, vol. 9, no. 1, pp. 1–3, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. J. J. M. Van Dongen, E. A. Macintyre, J. A. Gabert et al., “Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 concerted action: investigation of minimal residual disease in acute leukemia,” Leukemia, vol. 13, no. 12, pp. 1901–1928, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. D. J. Culligan, D. Stevenson, Y.-L. Chee, and D. Grimwade, “Acute promyelocytic leukaemia with t(11;17)(q23;q12-21) and a good initial response to prolonged ATRA and combination chemotherapy,” British Journal of Haematology, vol. 100, no. 2, pp. 328–330, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. J. H. Jansen, M. C. de Ridder, W. M. C. Geertsma et al., “Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor,” Blood, vol. 94, no. 1, pp. 39–45, 1999. View at Google Scholar · View at Scopus
  19. M. C. Petti, F. Fazi, M. Gentile et al., “Complete remission through blast cell differentiation in PLZF/RARα-positive acute promyelocytic leukemia: In vitro and in vivo studies,” Blood, vol. 100, no. 3, pp. 1065–1067, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. S. B. Han, J. Lim, Y. Kim, H. Kim, and K. Han, “A variant acute promyelocytic leukemia with t(11;17)(q23;q12); ZBTB16-RARA showing typical morphology of classical acute promyelocytic leukemia,” The Korean Journal of Hematology, vol. 45, no. 2, pp. 133–135, 2010. View at Publisher · View at Google Scholar
  21. E. Ohlsson, M. B. Schuster, M. Hasemann, and B. T. Porse, “The multifaceted functions of C/EBPα in normal and malignant haematopoiesis,” Leukemia, vol. 30, no. 4, pp. 767–775, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. L.-I. Lin, C.-Y. Chen, D.-T. Lin et al., “Characterization of CEBPA mutations in acute myeloid leukemia: Most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells,” Clinical Cancer Research, vol. 11, no. 4, pp. 1372–1379, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Girard, M. Tremblay, M. Humbert et al., “RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 33, pp. 13522–13527, 2013. View at Publisher · View at Google Scholar · View at Scopus