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Case Reports in Hematology
Volume 2017, Article ID 8174207, 3 pages
https://doi.org/10.1155/2017/8174207
Case Report

Heterozygous Hemoglobin Sherwood Forest Causing Polycythemia

1Department of Medicine, Brown University Alpert Medical School, Providence, RI, USA
2Division of Hematology and Oncology, Rhode Island Hospital, Providence, RI, USA
3Department of Pathology and Laboratory Medicine, Brown University Alpert Medical School, Providence, RI, USA

Correspondence should be addressed to Vikram M. Raghunathan; moc.liamg@nahtanuhgar.markiv

Received 18 June 2017; Accepted 24 August 2017; Published 28 September 2017

Academic Editor: Marie-Christine Kyrtsonis

Copyright © 2017 Vikram M. Raghunathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hemoglobin (Hb) Sherwood Forest is a rare high-affinity hemoglobin first described in 1977, arising from an Arg to Thr substitution at codon 104 of the beta chain. This hemoglobin variant has been identified in few individuals and has been associated with a compensatory erythrocytosis in the homozygous state. Prior scarce case reports have noted that heterozygotes for this variant are phenotypically normal. Here we present a patient who was evaluated in our hematology clinic for chronic erythrocytosis and was found to be heterozygous for Hb Sherwood Forest. No other primary or secondary cause of his polycythemia was identified. This is the first described case of heterozygous Hemoglobin Sherwood Forest causing erythrocytosis.