Case Reports in Hematology

Case Report

Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma

Table 1

Clinical features of patients with large B cell lymphoma initially manifesting in the bone marrow. Patients N1–N9 are from National Cheng Kung University Hospital; patients M1 and M2 are from University of Texas M.D. Anderson Cancer Center; and patient UM1 is from University of Miami. H/S: hepatomegaly/splenomegaly; HS: haemophagocytic syndrome; IPI: international prognostic index; C/T: chemotherapy; CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisolone (E, epirubicin); R-ESHAP: rituximab, etoposide, methylprednisolone, cytarabine, and cisplatin; CVAD: Cyclophosphamide, vincristine, doxorubicin hydrochloride (Adriamycin), and dexamethasone; PBSCT: peripheral blood stem cell transplantation; F: female; M: male [4].
Case Age/sexFeverH/SCytopeniaLDHHSRadiological splenic mass (>3 cm)TreatmentIPIOutcome (days)
N126/F+−/+Leukopenia and anemia293−—C/T (CHOP3, R-ESHAP), PBSCT2Alive (1560)
N273/F+−/+Anaemia and thrombocytopenia293+Many small hypodense nodulesC/T (CHOP1, R-CHOP5)3Dead (784)
N344/M+−/+Anaemia and thrombocytopenia745−Many small hypodense nodulesC/T (CEOP1, R-CEOP5, R-ESHAP4), PBSCT2Dead (551)
N454/M+−/+Pancytopenia727+—C/T (CHOP6)2Dead (285)
N580/M+−/+Anaemia and thrombocytopenia319+Wedge-shaped hypodense infarct—4Dead (17)
N672/F+−/+Anaemia and thrombocytopenia1255−——4Dead (8)
N776/M+−/+Anaemia and thrombocytopenia426+——4Dead (6)
N861/M+−/+Anaemia and thrombocytopenia160+——3Dead (4)
N975/M+−/+Anaemia and thrombocytopenia4464+Many small hypodense nodules—4Dead (4)
M169/M+−/+Anemia482−—C/T (R-CVAD6)4Dead (84)
M260/M++/+Anaemia and thrombocytopenia2266+Many small hypodense nodulesC/T (R-CVAD6)4Dead (224)
UM173/F++/+Thrombocytopenia, neutropenia and anemia1010+Numerous heterogeneous areas (2 to 5 cm)C/T (R-CHOP with steroids)4Dead (51)