Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma

Table 2

Differential diagnosis of LBCL-BLS and subtypes of IVLBCL and TCHRLBCL.

	LBCL-BLS	IVLBCL (Western type)	IVLBCL (Asian type)	TCHRLBCL
CD20	+	+	+	+
CD79a	+	+	+	+
CD3	−	−	−	Background T cells
CD5	−	38%+	38% +	Background T cells
EBV	−	−	−	+
HLH	+	+/−	+	−
Peripheral lymph node involvement	−	−	−	+
Involvement of vascular lumina by lymphoma cells	−	+	+	−
Specific Alterations	None	None	19q13 and 8p21	−
Organ of involvement	BM, liver and/or spleen	CNS or skin	BM	Liver, spleen, BM
T cell rich lymphoid nodules	−	−	−	+
HCV infection association	−	−	−	−
Bone marrow, rich in T cell nodules	−	−	−	+