Systemic Amyloidosis and Cardiac Autonomic Neuropathy Associated with Waldenstrom’s Macroglobulinemia

Table 1

Ewing’s battery of tests to assess cardiac autonomic neuropathy.

Test	Result	Normal	Borderline	Abnormal
Heart rate response to Valsalva maneuver (ratio of baseline to Valsalva)	1.17	≥1.21	1.11–1.20	≤1.10
Heart rate variation on deep breathing (expiration to inspiration in beats/minute)	8	≥15	11–14	≤10
Blood pressure response to sustained grip (before to after in mm of Hg)	17	≥16	11–15	≤10
Heart rate response from supine to standing position (ratio of R-R interval change in response to change in position from supine to standing)	0.72	≥1.04	1.01–1.03	≤1.00
Blood pressure response from supine to standing position (supine to standing in mm of Hg)	31	≤10	11–29	≥30