Thrombotic Thrombocytopenic Purpura due to Checkpoint Inhibitors

Table 1

Laboratory studies on admission.

Variable	On admission
Hgb	6 g/dL
HCT	18.7%
PLT	20,000 per microliter
LDH	998 U/L
Total bilirubin	1.9 mg/dL
Creatinine	0.9 mg/dL
D-dimer	7342 ng/mL
Haptoglobin	<10 mg/dL
Fibrinogen	349 mg/dL
PT	12 sec
INR	1
PTT	31 sec
Heparin-induced anti-PF4 antibodies	0.312
Direct Coomb’s test	Negative
Blood culture	Negative
Urine culture	Negative
Peripheral blood smear	Fragmented erythrocytes; Polychromasia; Nucleated RBCs; Schistocytes