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Author | Year | Patients/disease | Site of complication | Chemotherapy regimen and onset of event (day after receiving chemotherapy) | Treatment of pericarditis or pericardial effusion | Results |
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Vaickus and Letendre | 1984 | 25-year-old man with relapsed ALL | PC/PEEF with cardiac tamponade | Day 2 after the fourth dose of the second cycle of high-dose Ara-C (3 g/M2 for 10 doses/cycle) (consolidation) | Prednisolone 10 mg twice daily and salicylate 500 mg twice daily for 2 days, but no response; pericardiocentesis was performed | Full recovery after pericardiocentesis |
Gillis et al. | 1992 | 51-year-old woman | PC with minimal PEEF | Day 3 after the fifth dose of the first cycle of high-dose Ara-C (3 g/M2 for 12 doses/cycle) (consolidation) | Hydrocortisone 200 mg once daily intravenously | Full recovery within a week without pericardiocentesis |
Reykdal et al. | 1995 | 47-year-old man with AML-M4 | PC, no PEEF | Day 11 after the last dose of the first cycle of high-dose Ara-C (2 g/M2 every 12 hours for 6 days) (consolidation) | Supportive treatment with NSAIDs | Pain relieved by NSAIDs within a day |
Hermans et al. | 1997 | 37-year-old man with AML-M2 | PC/PEEF | Day 4 after the 5th dose of 3rd cycle of high-dose Ara-C (3 g/M2 every 12 hours for 4 days) (consolidation) | Methylprednisolone 0.5 mg/kg orally for 8 days, and tapered off at day 11 | Complete recovery by day 7 of methylprednisolone |
Yamada et al. | 1998 | 61-year-old man with AML-M2 and 65-year-old man with MDS-related AML-M2 | PEEF | Relapsed AML, low-dose Ara-C (induction remission) AML-M2 low-dose Ara-C (consolidation) | Pulse methylprednisolone plus pericardiocentesis | Not reported |
Woods et al. | 1999 | 47-year-old man with AML-M2 | Large PEEF | Day 9 after the first induction remission with daunorubicin and Ara-C (100 mg/M2 D1-7); then, high-dose Ara-C (2 g/M2 on D8-10) (induction remission) | Pericardiocentesis | Recovery by 6 weeks |
Gähler et al. | 2003 | 64-year-old man with AML-M4 | 1st: PC/small PEEF | 1st episode: day 29 after 7 + 3 regimen (200 mg/M2 Ara-C) (induction remission) | 1st: NSAIDs | Recovery in 48 hours |
2nd: PC with PEEF and cardiac tamponade | 2nd episode: day 3 after high-dose Ara-C (1 g/M2 every 12 hours for 6 days) (consolidation) | 2nd: Pericardiocentesis | Immediately improved after pericardiocentesis |
Lee et al. | 2011 | 25-year-old woman with AML-M4 | Recurrent PC | 1st episode: day 6 after the sixth dose of high-dose Ara-C (second cycle of induction remission) | 1st: high-dose ibuprofen (1,200 mg/day) | Responded well |
2nd episode: day 2 after the sixth dose of high-dose Ara-C (first consolidation) | 2nd: high-dose ibuprofen (1,200 mg/day) + colchicine (0.6 mg/day) | Responded well within 10 days |
This study | 2017 | 38-year-old woman with AML-M4 | PC/PEEF | Day 3 after the fourth dose of high-dose Ara-C (first consolidation) | Dexamethasone 10 mg intravenously once daily | Complete recovery within 3 days |
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