Bradycardia during Induction Therapy with All-trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia: Case Report and Literature Review

Figure 1

Serial electrocardiogram changes. (a) Normal sinus rhythm before the induction therapy (PR interval 206 ms, QTc 429 ms). (b) The 11th day of therapy, showing complete AV block (PR interval > 400 ms, QTc 395 ms). (c) Restoration of normal sinus rhythm after pacemaker removal (PR interval 192 ms, QTc 353 ms).

(a)

(b)

(c)