Rivaroxaban Treatment for Warfarin-Refractory Thrombosis in a Patient with Hereditary Protein S Deficiency

Table 1

Coagulation studies of the patient and her two daughters.

		Normal range	Patient (91 years)					Daughter 1 (66 years)	Daughter 2 (54 years)
			Period after warfarin cessation			Period after rivaroxaban
			2 weeks	4 weeks	5 weeks	2 weeks	3 weeks
Total PS antigen	%	65–135	—	52	54	57	54	62	53
Free PS antigen	%	60–150	—	25	30	27	27	29	25
PS activity	%	56–126	<10	—	—	—	—	—	—
PC activity	%	64–146	40	120	—	—	—	156	131
PT-INR			1.11	0.96	1.00	0.89	0.85	1.02	1.10
II	%	75–135	—	76	—	—	—	—	—
VII	%	75–140	—	146	—	—	—	—	—
IX	%	70–130	—	105	—	—	—	—	—
X	%	70–130	—	85	—	—	—	—	—

PS: protein S; PC: protein C; PT-INR: prothrombin time-international normalized ratio.