Case Report

Myasthenia Gravis Presenting as Graft versus Host Disease after Allogeneic Blood Stem Cell Transplant

Table 1

Diagnostic testing.

MRI brainNo acute cerebral infarction

Cerebrospinal fluidGlucose 54, RBC 21, protein 25, WBC 7, 10% segmented neutrophils

Autoimmune, rheumatologic: anti Jo -1, RNP, SRP, PL-12, PL-7, PM-SCL 100, PM-SCL 75, RO-52, JO-1, antimyeloperoxidase, ANA, C-ANCA, P-ANCA, rheumatoid factorNegative

Infectious: parvovirus B19, hepatitis A, hepatitis B, hepatitis C, EBV, west nile, CMVNegative

Electromyography studiesSevere axonal neuropathy or demyelination. No evidence of neuromuscular junction disorder or myopathy

Acetylcholine receptor binding antibodyElevated, 2.15 nmol/L (normal: 0–0.24)
Acetylcholine receptor modulating antibody AChR binding Ab45% (normal: 0–20%)