Treatment Sequencing in a Chronic Lymphocytic Leukemia Patient with Central Nervous System Involvement

Figure 1

B-CLL characterization. (a) Bone marrow biopsy (HE): in September 2015, there was a 70% nodular and interstitial infiltration of small lymphocytes. (b) Bone marrow smear (MGG): in January 2016, numerous small lymphocytes, with clumped chromatin and scanty cytoplasm, smudge cells, and a few erythroblasts were detected. Dot plots illustrating cerebral spinal fluid (CSF), immunophenotyping CD5⁺/CD19⁻ T cells (red dots) and CD19⁺/CD5⁺ B-CLL cells (black dots) in October 2015 (c) and in August 2017 (d). Magnification: (a) ×40 (left), ×100 (center), and ×600 (right) and (b) ×100.

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