Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hematology
Volume 2018, Article ID 8097965, 4 pages
Case Report

Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis

1Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA
2Division of Pathology, University of Illinois at Chicago, Chicago, IL, USA
3Department of Pathology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA

Correspondence should be addressed to X. A. Andrade; moc.liamtoh@81ga_reivax

Received 31 August 2017; Revised 10 December 2017; Accepted 11 December 2017; Published 11 January 2018

Academic Editor: Tatsuharu Ohno

Copyright © 2018 X. A. Andrade et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein–Barr virus infection. Lymphoid malignancies of T-cell origin are uncommon in patients with rheumatoid arthirits. Clinical presentation with associated hemophagocytic lymphohistiocyotsis is rare and confers a poor prognosis. This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy.