Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements

Figure 2

(a) Hematoxylin and eosin stain 40x: the lighter staining nodular areas contain the larger cells of the blastoid variant mantle cell lymphoma (MCL). The darker staining areas near the center contain the small cells of the small lymphocytic lymphoma (SLL) component. (b) Hematoxylin and eosin stain 400x: the larger cells of the MCL are on the left and smaller cells of the SLL are on the right. (c) The MCL and SLL both stain for CD20. The SLL displays weaker staining. (d) The large nodules of the MCL stain weakly for CD3. The SLL is negative. (e) Both MCL and SLL stain for CD5. (f) Only the nodules of MCL stain for CD10. The SLL is negative. (g, h) The MCL stains for CyclinD1 (BCL-1) and SOX-11. The SLL component is negative. (i) The SLL in the center stains for CD23. (j) Many cells in the MCL nodules stain with Ki-67 indicating a high proliferation rate, whereas very few stain in the center SLL region stain indicating a low proliferation rate.

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