Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements

Figure 3

Flow cytometry on the bone marrow. (a) The following images come from the region gated as “lymphocytes”. (b, c) The B-cells are small in size by forward light scatter and express moderate intensity CD19 and dim intensity CD20, a feature typical of chronic lymphocytic lymphoma/small lymphocytic lymphoma (CLL/SLL). This differs from the large size and intensity of these antigens in the mantle cell lymphoma of the lymph node. (d, e) The small B-cells stain for CD5 but are negative for CD3. The cells expressing bright CD3 are the T-cells. (f) A region color coded with orange represents the B-cells coexpressing CD5. (g, h) These cells do not express CD10 and the surface light chain expression is negative or equivocal.

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