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Case Reports in Hematology
Volume 2018, Article ID 8765285, 3 pages
Case Report

Prolonged Survival of Acute Lymphoblastic Leukemia with Intrathecal Treatments for Isolated Central Nervous System Relapse

1Rutgers Robert Wood Johnson Medical School, 3rd Floor, New Brunswick, NJ, USA
2Hackensack Meridian Health Jersey Shore University, 1945 Route 33, Ackerman Building, 3rd Floor, Neptune, NJ 07753, USA
3Bayer U.S. LLC, 100 Bayer Boulevard, Whippany, NJ 07891-0915, USA

Correspondence should be addressed to Elan Gorshein; moc.liamg@niehsrog.nale

Received 12 December 2017; Revised 29 December 2017; Accepted 3 January 2018; Published 31 January 2018

Academic Editor: Massimo Gentile

Copyright © 2018 Elan Gorshein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute lymphoblastic leukemia is commonly cured when diagnosed in the pediatric population. It portends a poorer prognosis if present in adult patients. Although adults frequently achieve complete remission, relapse rates are substantial, particularly among the elderly and high-risk populations. In the absence of prophylactic intrathecal chemotherapy, more than half of patients may develop CNS involvement or relapse, which is associated with significant risk for systemic illness. This report describes a patient with acute lymphoblastic leukemia with repeated isolated CNS relapses. This case should remind clinicians that isolated CNS disease in the absence of systemic recurrence could successfully respond to intrathecal therapy and offer patients a favorable quality of life.