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Case Reports in Hematology
Volume 2018 (2018), Article ID 9191582, 11 pages
https://doi.org/10.1155/2018/9191582
Case Report

Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases

1Department of Pathology, Ohio State University, Columbus, OH, USA
2Department of Internal Medicine, University of South Florida, Tampa, FL, USA
3Bone Marrow Transplant Program, Moffitt Cancer Center, Tampa, FL, USA
4Moffitt Cancer Center, Tampa, FL, USA
5Mayo Clinic, Rochester, MN, USA

Correspondence should be addressed to Abu-Sayeef Mirza; ude.fsu.liam@aazrim

Received 5 November 2017; Accepted 31 December 2017; Published 28 February 2018

Academic Editor: Salah Aref

Copyright © 2018 Michael Markow et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nonhepatosplenic/noncutaneous γδ peripheral T-cell lymphoma (NHNCγδ PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNCγδ PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells. Among other notable molecular characteristics, expression of immature markers such as TdT was lost in both cases. Based on cytogenetics, phenotype, and morphology, both patients represent a novel phenomenon of clonal transformation from T-ALL to PTCL which has rarely been reported in the literature. Such transformation may carry important diagnostic and biological implications.