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Case Reports in Hematology
Volume 2018, Article ID 9368451, 5 pages
Case Report

Primary Effusion Lymphoma without an Effusion: A Rare Case of Solid Extracavitary Variant of Primary Effusion Lymphoma in an HIV-Positive Patient

1Division of Hematology and Oncology, University of Louisville, Louisville, KY, USA
2Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA
3Division of Blood and Marrow Transplant, University of Louisville, Louisville, KY, USA

Correspondence should be addressed to Hamza Hashmi; moc.liamtoh@78imhsahazmah

Received 26 August 2017; Revised 5 December 2017; Accepted 27 December 2017; Published 28 January 2018

Academic Editor: Tatsuharu Ohno

Copyright © 2018 Hamza Hashmi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, usually seen in severely immunocompromised, HIV-positive patients. PEL is related to human herpesvirus-8 (HHV-8) infection, and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumor mass. There have been very few case reports of HIV-positive patients with HHV-8-positive solid tissue lymphomas not associated with an effusion (a solid variant of PEL). In the absence of effusion, establishing an accurate diagnosis can be challenging, and a careful review of morphology, immunophenotype, and presence of HHV-8 is necessary to differentiate from other subtypes of non-Hodgkin lymphoma. Treatment involves intensive chemotherapy, and prognosis is usually poor. We present a rare case of a PEL variant in an HIV-positive patient who presented with extensive lymphadenopathy without any associated effusions.