Plasmablastic Lymphoma, a Rare Entity in Bone Marrow with Unusual Immunophenotype and Challenging Differential Diagnosis

Figure 2

Bone marrow biopsy and aspirate smears show high-grade hematopoietic neoplasm. (a) The neoplasm has a diffuse growth pattern on core biopsy (H&E stain, ×100). (b) The neoplastic cells have irregular nuclear contours, conspicuous nucleoli, and abundant cytoplasm (H and E stain, ×400). (c) Bone marrow aspirate shows discohesive high-grade hematopoietic tumor cells (Wright–Giemsa, ×100). (d) The hematopoietic cells have slightly eccentric nuclei, prominent nucleoli, and deep blue vacuolated cytoplasm. Occasional plasma cells are seen in the background (Wright–Giemsa, ×600).

(a)

(b)

(c)

(d)