The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma

Figure 3

Pathological autopsy findings. (a) Bone marrow contained large basophilic cells with perinuclear halo and proliferation of large cells with distinct nucleoli, which were positive for IgA on immunostaining. (b, c) In the kidneys, the distal convoluted and collecting tubules were filled with eosinophilic amorphous deposits, which was positive for κ light chain. (d, e, f) Fibrosis and disarray were observed between the myocardial cells, and these myocardial cells showed basophilic degeneration. Invaded inflammatory cells were positive for CD3 but negative for CD79a.