Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review

Table 1

T-cell lymphoblastic lymphomas with cutaneous involvement reported in the literature.

Source	Sex/age	Cutaneous location	Extracutaneous involvement	Immunohistochemical profile	Treatment	Disease status at last follow-up
Nascimbeni et al. [13]	M/66y	Scalp and trunk	BM and retroperitoneal LN	CD2, CD7, CD3, CD99, TdT, C-kit	Four cycles of CHOP with intrathecal MTX	Complete remission
Ginoux et al. [14]	M/75y	Right arm and occipital area	Bilateral LN on axillary, cervical, and inguinal areas, BM	CD3, CD5, CD4, Ki67, TdT	CHOP	Died 8 Mo after diagnosis
Lee et al. [2]	M/16y	Subcutaneous nodule on the neck	BM, LN	CD99, CD3, CD45RO, TdT	Unspecified chemotherapy	Died 2 y after diagnosis
Lee et al. [2]	M/20y	Multiple scalp nodules	Prostate	CD3, CD4, CD8, CD10, CD99, CD45RO, TdT	Unspecified chemotherapy	Died 5 Mo after diagnosis
Lee et al. [2]	M/25y	Multiple subcutaneous nodules on face, scalp, chest wall	BM, LN, scrotal involvement	CD3, CD10, CD99, CD45RO, TdT	Unspecified chemotherapy	Complete remission 8 y after diagnosis
Lee et al. [2]	M/17y	Subcutaneous nodules on neck and abdomen.	Mediastinal mass, BM, LN	CD3, CD99, CD45RO, TdT.	Unspecified chemotherapy	Complete remission 9 y after diagnosis
Lee et al. [2]	F/25y	Multiple subcutaneous nodules on right breast, neck, chest wall, legs	BM, LN	CD3, CD4, CD8, CD33, CD99, TdT	Unspecified chemotherapy	Relapse
Lee et al. [2]	M/39y	Multiple nodules on scalp	Mediastinal mass, LN, BM, left kidney, pleura	CD3, CD4, CD8, CD10, CD1a, TdT	Unspecified chemotherapy	Complete remission 3 y after diagnosis
Lee et al. [2]	M/22y	Multiple subcutaneous nodules on back	Mediastinal mass, LN, tonsil, nasopharynx	CD3, CD8, CD10, CD45RO, TdT	Unspecified chemotherapy	Partial remission
Vezzoli et al. [5]	F/29y	Multiple nodules on face, breast, thoracomammary region, abdomen, thighs	Primary cutaneous with axillary LN, 23 Mo after diagnosis	CD3, CD5, CD7, CD99, CD45RA, CD79a, KI67, TdT	DHAP + pro MACE cytaBOM + ABSCT	Died after 28 Mo diagnosis
Yaar et al. [15]	M/27y	Cutaneous nodule right cheek and forehead	Mediastinal mass, BM	CD3, CD5, CD7, CD45, CD34, Ki-67	Not described	Not described
Prasad et al. [16]	M/5y	Noduloulcerative purplish lesions on abdominal wall	St Judes stage III unspecified extracutaneous involvement	CD3, CD45, TdT	Not described	Not described
Chimenti et al. [17]	M/65y	Abdomen and extremities	BM	CD1a, CD3, CD43, CD99, TdT	Not described	Died 2 Mo after diagnosis
Sander et al. [9]	F/24y	Malar region, anterior chest wall, breasts	Submental LN, liver, BM	CD2, CD4, CD7, CD10, CD13, TdT	Cyclophosphamide, cytosine, arabinoside, teniposida, deoxycoformycin, vincristine	Died 21 Mo after diagnosis
Sander et al. [9]	M/25y	Scalp	Mediastinal mass, cervical, supraclavicular, axillary LN	CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD10, TdT	Whole brain XRT, intrathecal MTX, cyclophosphamide, doxorubicin, vincristine, L-asparaginas, mercaptopurine	Complete remission

M: male; F: female; Mo: months; y: years; LN: lymph node; BM: bone marrow; MTX: methotrexate; XRT: radiation therapy; DHAP: cytosine arabinoside, cisplatin, and dexamethasone; ProMACE-cytaBOM: cyclophosphamide, methotrexate, vincristine, etoposide, epirubicin, bleomycin, and cytarabine; ABSCT: autologous bone marrow stem cell transplant.