An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review

Figure 2

The structures of MLL, EP300, and MLL-EP300 fusion protein and the sequence of the fusion gene. RNA sequencing and RT-PCR followed by Sanger sequencing demonstrated that MLL exon 10 was fused in-frame to EP300 exon 15. The breakpoint is indicated by the arrow and dashed line. MBD, menin-binding domain; AT, AT hooks; NLS, nuclear localization signal; CxxC, motif recognizing unmethylated CpG dinucleotides; PHD, plant homeodomain fingers; BD, bromodomain; TAD, transactivation domain; SET, H3K4 histone methyltransferase domain; TAZ, transcriptional-adaptor zinc-finger domain; CH, cysteine/histidine-rich regions; KIX, kinase-inducible domain of the CREB-interacting domain; KAT, lysine acetyltransferase domain.