HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient

Figure 1

Pathologic findings in an inguinal lymph node core biopsy. (a) Germinal center showing large atypical plasmablasts. The arrow indicates the germinal center (H&E, 200x). (b) Germinal center, arrows point to plasmablasts (H&E, 500x). (c) The plasmablasts (arrow) are positive for HHV-8 (immunostaining, anti-HHV-8 (13b10) mouse monoclonal antibody by Cell Marque, 200x). (d, e) The germinal center (black arrows) contains lambda-light chain-restricted plasmablasts (in situ hybridization, DNA probes by Ventana that react with lambda mRNA and Kappa mRNA, respectively, 200x). The paracortex adjacent to the germinal center contains polyclonal plasma cells (blue arrows). (f) EBV-positive cells throughout the lymph node core biopsy (EBER in situ hybridization, DNA probe to EBV-encoded RNA-1 by Ventana, 100x).

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