Aplasia in Chronic Phase CML Post-TKI Therapy: A Management Dilemma

Figure 1

Hematologic parameters in patients with CML treated with imatinib, dasatinib, subsequent BMT, and ponatinib following relapse. White blood cells (WBC), hemoglobin (Hb), and platelets (PLTs) are depicted over a 36-month period until the last day of patient follow-up. The graph is divided into seven frames: (1) initial response to imatinib 100 mg followed by (2) discontinuation due to pancytopenia. (3) Treatment was switched to dasatinib 100 mg followed by (5) subsequent reductions in dosing in the setting of persistent pancytopenia. (6) The patient was switched to omacetaxine due to proven panmyeloid hypoplasia leading to (8) BMT. (9) The patient was started on ponatinib due to relapsed disease.