First Report of Hereditary Lysozyme Amyloidosis in a South Asian Family

Table 1

Families reported in the literature with Alys.

Family	Mutation	Ethnicity	Dominant clinical features
1	W64R/TGG/CGG	French [1]	Nephropathy/Sicca syndrome
2	W64R/TGG/AGG	Italian [2]	Gastrointestinal
3	W64R/TGG/AGG	Italian [3]	Gastrointestinal
4	W64R/TGG/AGG	French [4]	Internal organ bleeding
5	I56T	English [5]	Nephropathy/easy bruisability
6	F57I	Italian [6]	Nephropathy
7	D67H	English [7]	Internal organ bleeding
8	D67H	English [8]	Nephropathy/GI bleeding
9	pTyr54Asn	Swedish [9]	Gastrointestinal/Sicca syndrome
10	I56T (our case)	South Asian	Gastrointestinal/nephropathy/internal organ bleeding
11	p.Leu102Ser	English with mixed lineage [10]	Nephropathy/neuropathy/gastrointestinal/cardiac
12	W64R/TGG/AGG	Italian [11]	Gastrointestinal
13	Mutation not specified; however, lysozyme C confirmed as amyloidogenic protein per LCMS	English [12]	Nephropathy/internal organ bleeding
14	D67H	English [13]	Internal organ bleeding