Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports

Table 1

Clinical characteristics and laboratory findings of the patients.

Clinical and laboratory findings	Patient 1	Patient 2	Patient 3
Age at diagnosis (m)	115	64	141
Clinical presentation	Bone pain, adenopathy, and hepatosplenomegaly	Fever, pale appearance, adenopathy, and hepatosplenomegaly	Pale appearance, ecchymosis, headache, adenopathy, and hepatosplenomegaly
WBC count (×10^9/L)	107.21	299.36	223.39
PLT count (×10^9/L)	140	20	22
Hb level (g/L)	126	58	88
Blasts in PB	0.86	0.95	0.89
BM smear	ALL-L2	ALL-L2	ALL-L2
BM biopsy	B-ALL	B-ALL	B-ALL
Immunophenotype	Common B-ALL	Common B-ALL	Common B-ALL
Chromosomal karyotype	45, XY, −7, t(9;22)(q34;q11)	45, XY, −20, t(9;22)(q34;q11)	45, XY, −7, t(9;22)(q34;q11)
FISH for BCR-ABL1	(+), 90%	(+), 96%	(+), 85%
Fusion gene screening	BCR-ABL1(P210)	BCR-ABL1(P190)	BCR-ABL1(P210)
IS BCR-ABL1	1.049	0.743	0.126

WBC: white blood cell; PLT: platelet; Hb: hemoglobin; PB: peripheral blood; BM: bone marrow; FISH: fluorescence in situ hybridization.