A Case Report with Severe Thrombocytopenia Induced by Axitinib

Table 1

Hematologic adverse effects in major trials of Axitinib.

	Axi vs Placebo (Atlas) [8]	Axi vs. sorafenib (Front-line) [9]	Axi + pembrolizumab (KEYNOTE 426) [7]	Axi + avelumab (JAVELIN 101) [5]		Axi vs. sorafenib (AXIS) [6]
	Any grade	Any grade	Any grade	Grade ≥3	All grades	Grade ≥3	Grade ≥3
Anemia	NR	NR	7.9	0.7	6	1.6	<1
Neutropenia	2	NR	1.9	0.2	1.4	0.2	1
Lymphopenia	NR	NR	NR	NR	NR	NR	3
Thrombocytopenia	2	NR	2.6	0	3.5	0.2	<1

NR: not reported; <2%.